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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62050
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnni2
Name: troponin I2, fast skeletal type
Acc ID: CHEBI:9986
Term: vinclozolin
Definition: A racemate comprising equimolar amounts of (R)- and (S)-vinclozolin. A fungicide used mainly on oilseed rape, vines, fruit and vegetables to control Botrytis, Sclerotinia and Monilia spp.
Chemical ID: MESH:C025643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDvinclozolin results in decreased expression of TNNI2 mRNA

PMID:20566332
increases expressionEXP 6480464CTDvinclozolin results in increased expression of TNNI2 mRNA

PMID:23160963
multiple interactionsEXP 6480464CTD[Genistein co-treated with vinclozolin] results in increased expression of TNNI2 mRNA

PMID:23160963
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.