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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3318
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1b
Name: ATP-binding cassette, sub-family B member 1B
Acc ID: CHEBI:9948
Term: verapamil
Definition: A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
Chemical ID: MESH:D014700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1bdecreases activityEXP 6480464CTDVerapamil results in decreased activity of ABCB1B proteinPMID:12202523
Abcb1baffects response to substanceISOAbcb1b (Mus musculus)6480464CTDABCB1B protein affects the susceptibility to VerapamilPMID:15502009
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