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RGD ID: 11452
Species: Mus musculus
RGD Object: Gene
Symbol: Trh
Name: thyrotropin releasing hormone
Acc ID: CHEBI:9948
Term: verapamil
Definition: A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
Chemical ID: MESH:D014700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trhmultiple interactionsISORGD:691546480464CTDVerapamil inhibits the reaction [TRH protein results in increased secretion of TSHB protein], Verapamil promotes the reaction [TRH protein results in increased secretion of PRL protein]

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.