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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737190
Species: Mus musculus
RGD Object: Gene
Symbol: Agtr1a
Name: angiotensin II receptor, type 1a
Acc ID: CHEBI:9927
Term: valsartan
Definition: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Chemical ID: MESH:C081489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Agtr1amultiple interactionsEXP 6480464CTDValsartan promotes the reaction [Streptozocin results in increased expression of AGTR1 protein]PMID:29266779
Agtr1adecreases expressionISOAgtr1a (Rattus norvegicus)6480464CTDValsartan results in decreased expression of AGTR1A mRNAPMID:18403896
Agtr1amultiple interactionsISOAGTR1 (Homo sapiens)6480464CTDValsartan binds to and results in decreased activity of AGTR1 proteinPMID:28973481
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