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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735618
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: CHEBI:9927
Term: valsartan
Definition: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Chemical ID: MESH:C081489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3decreases expressionISONos3 (Rattus norvegicus)6480464CTDValsartan results in decreased expression of NOS3 proteinPMID:31023080
NOS3multiple interactionsISONos3 (Mus musculus)6480464CTDValsartan inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NOS3 protein]PMID:18436887
NOS3multiple interactionsISONos3 (Rattus norvegicus)6480464CTD[fluvastatin co-treated with Valsartan] results in increased expression of NOS3 mRNA; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]]PMID:11897773 PMID:28951255
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