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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732783
Species: Homo sapiens
RGD Object: Gene
Symbol: KL
Name: klotho
Acc ID: CHEBI:9927
Term: valsartan
Definition: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Chemical ID: MESH:C081489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KLincreases expressionISOKl (Rattus norvegicus)6480464CTDValsartan results in increased expression of KL mRNA; Valsartan results in increased expression of KL proteinPMID:21051829
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