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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69096
Species: Mus musculus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:9927
Term: valsartan
Definition: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Chemical ID: MESH:C081489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1multiple interactionsEXP 6480464CTDValsartan inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]PMID:29266779 PMID:33631230
Tgfb1decreases expressionISOTgfb1 (Rattus norvegicus)6480464CTDValsartan results in decreased expression of TGFB1 proteinPMID:15619341 PMID:16928621
Tgfb1decreases expressionISOTGFB1 (Homo sapiens)6480464CTDValsartan results in decreased expression of TGFB1 proteinPMID:17680535 PMID:18390891
Tgfb1multiple interactionsISOTgfb1 (Rattus norvegicus)6480464CTD[Tacrolimus co-treated with Valsartan] results in increased expression of TGFB1 protein; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Ovalbumin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]PMID:11798641 PMID:16115399 PMID:16549154 PMID:16872305 PMID:17703430 PMID:19080339 PMID:23733546 PMID:35114312
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTD[benazepril co-treated with Valsartan] results in decreased expression of TGFB1 proteinPMID:18390891
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