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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrnb4
Name: cholinergic receptor nicotinic beta 4 subunit
Acc ID: CHEBI:9774
Term: tubocurarine
Definition: A benzylisoquinoline alkaloid muscle relaxant which constitutes the active component of curare.
Chemical ID: MESH:D014403
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrnb4multiple interactionsEXP 6480464CTDTubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA2 protein]]; Tubocurarine promotes the reaction [Acetylcholine binds to and results in increased activity of [CHRNB4 protein binds to CHRNA3 protein]]; Tubocurarine results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]PMID:7808438 PMID:9687574
Chrnb4multiple interactionsISOCHRNB4 (Homo sapiens)6480464CTDTubocurarine inhibits the reaction [Acetylcholine results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]; Tubocurarine inhibits the reaction [desnitroimidacloprid results in increased activity of [CHRNA3 protein binds to CHRNB4 protein]]PMID:16931985 PMID:34628512
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