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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730847
Species: Mus musculus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8increases expressionEXP 6480464CTDtroglitazone results in increased expression of CASP8 mRNAPMID:28973697
Casp8decreases expressionISOCASP8 (Homo sapiens)6480464CTDtroglitazone results in decreased expression of CASP8 mRNAPMID:19631733
Casp8increases activityISOCASP8 (Homo sapiens)6480464CTDtroglitazone results in increased activity of CASP8 proteinPMID:14508522
Casp8increases expressionISOCASP8 (Homo sapiens)6480464CTDtroglitazone results in increased expression of CASP8; troglitazone results in increased expression of CASP8 mRNA; troglitazone results in increased expression of CASP8 protein modified formPMID:12680223 PMID:16820965 PMID:19631733
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