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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a9
Name: cytochrome P450, family 3, subfamily a, polypeptide 9
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a9decreases expressionISOCYP3A5 (Homo sapiens)6480464CTDtroglitazone results in decreased expression of CYP3A5PMID:15618651
Cyp3a9increases metabolic processingISOCYP3A5 (Homo sapiens)6480464CTDCYP3A5 protein results in increased metabolism of troglitazonePMID:19356091
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