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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDtroglitazone results in decreased expression of SREBF1 mRNA

PMID:10900012
multiple interactionsEXP 6480464CTD[[[troglitazone binds to and results in increased activity of PPARG protein] which results in decreased localization of and results in decreased activity of SREBF1 protein] which results in decreased expression of FASN mRNA] which results in decreased abundance of Triglycerides, [troglitazone binds to and results in increased activity of PPARG protein] which results in decreased localization of and results in decreased activity of SREBF1 protein

PMID:19248225
decreases expressionISORGD:694736480464CTDtroglitazone results in decreased expression of SREBF1 mRNA

PMID:19140230
multiple interactionsISORGD:694736480464CTD[1-Methyl-3-isobutylxanthine co-treated with troglitazone co-treated with INS protein] results in increased expression of SREBF1 mRNA

PMID:27003841
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.