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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68556
Species: Homo sapiens
RGD Object: Gene
Symbol: CCND1
Name: cyclin D1
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCND1decreases expressionEXP 6480464CTDtroglitazone results in decreased expression of CCND1 mRNA; troglitazone results in decreased expression of CCND1 proteinPMID:12595159 PMID:12680223 PMID:17143939 PMID:17409431 PMID:18162602 PMID:20540935 PMID:22684020 PMID:22750490
CCND1increases degradationEXP 6480464CTDtroglitazone results in increased degradation of CCND1 proteinPMID:17409431
CCND1increases expressionEXP 6480464CTDtroglitazone results in increased expression of CCND1 mRNA; troglitazone results in increased expression of CCND1 proteinPMID:11834241 PMID:19022234
CCND1multiple interactionsEXP 6480464CTD[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [troglitazone results in decreased expression of CCND1 protein]; GSK3B protein affects the susceptibility to [troglitazone results in decreased expression of CCND1 protein]PMID:20540935
CCND1decreases expressionISOCcnd1 (Rattus norvegicus)6480464CTDtroglitazone results in decreased expression of CCND1 mRNAPMID:21515302
CCND1decreases expressionISOCcnd1 (Mus musculus)6480464CTDtroglitazone results in decreased expression of CCND1 mRNA; troglitazone results in decreased expression of CCND1 proteinPMID:15610522
CCND1increases expressionISOCcnd1 (Mus musculus)6480464CTDtroglitazone results in increased expression of CCND1 mRNAPMID:17569031
CCND1multiple interactionsISOCcnd1 (Mus musculus)6480464CTD[Urethane co-treated with troglitazone] results in increased expression of CCND1 mRNAPMID:18465119
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