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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621392
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn2
Name: cellular communication network factor 2
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccn2decreases expressionISOCCN2 (Homo sapiens)6480464CTDTroglitazone results in decreased expression of CCN2 mRNAPMID:25572481
Ccn2increases expressionISOCCN2 (Homo sapiens)6480464CTDTroglitazone results in increased expression of CCN2 mRNAPMID:19140230
Ccn2multiple interactionsISOCCN2 (Homo sapiens)6480464CTD[Troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of CCN2 mRNA; Troglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of CCN2 mRNA]; Troglitazone inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; Troglitazone inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]PMID:17056281 PMID:19429239 PMID:20847119
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