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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619554
Species: Homo sapiens
RGD Object: Gene
Symbol: CD36
Name: CD36 molecule (CD36 blood group)
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CD36decreases expressionEXP 6480464CTDtroglitazone results in decreased expression of CD36 mRNAPMID:28903485
CD36increases expressionEXP 6480464CTDTroglitazone results in increased expression of CD36 mRNA; Troglitazone results in increased expression of CD36 proteinPMID:14977855 PMID:18155510 PMID:22124178 PMID:25572481 PMID:27358406
CD36multiple interactionsEXP 6480464CTDafimoxifene inhibits the reaction [Troglitazone results in increased expression of CD36 protein]; T 0070907 inhibits the reaction [Troglitazone results in increased expression of CD36 mRNA]; Tamoxifen inhibits the reaction [Troglitazone results in increased expression of CD36 protein]PMID:22124178 PMID:27358406
CD36increases expressionISOCd36 (Rattus norvegicus)6480464CTDtroglitazone results in increased expression of CD36 mRNAPMID:21515302
CD36increases expressionISOCd36 (Mus musculus)6480464CTDtroglitazone results in increased expression of CD36 mRNAPMID:11089532 PMID:11231916 PMID:20854809 PMID:28973697
CD36multiple interactionsISOCd36 (Rattus norvegicus)6480464CTD[troglitazone co-treated with Ethanol] results in increased expression of CD36 protein; alpha-Tocopherol inhibits the reaction [[troglitazone co-treated with Ethanol] results in increased expression of CD36 protein]PMID:16407258
CD36multiple interactionsISOCd36 (Mus musculus)6480464CTD[troglitazone results in increased activity of PPARG protein] which results in increased expression of CD36 mRNA; tanshinone inhibits the reaction [troglitazone results in increased expression of CD36 mRNA]; troglitazone inhibits the reaction [tanshinone results in decreased expression of CD36 mRNA]PMID:11089532 PMID:20854809
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