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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2multiple interactionsEXP 6480464CTD[SOD2 co-treated with CYP3A4] affects the susceptibility to troglitazonePMID:19501153
Sod2affects response to substanceISOSod2 (Mus musculus)6480464CTDSOD2 protein affects the susceptibility to troglitazonePMID:17150972 PMID:18495193
Sod2decreases expressionISOSod2 (Mus musculus)6480464CTDtroglitazone results in decreased expression of SOD2 mRNAPMID:12732648
Sod2decreases expressionISOSOD2 (Homo sapiens)6480464CTDtroglitazone results in decreased expression of SOD2; troglitazone results in decreased expression of SOD2 mRNA; troglitazone results in decreased expression of SOD2 proteinPMID:20860658 PMID:23964924
Sod2increases expressionISOSod2 (Mus musculus)6480464CTDtroglitazone results in increased expression of SOD2 proteinPMID:18495193 PMID:28973697
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDtroglitazone results in increased expression of SOD2 mRNAPMID:19140230
Sod2multiple interactionsISOSod2 (Mus musculus)6480464CTDSOD2 protein affects the reaction [troglitazone results in increased abundance of Superoxides]PMID:17150972
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [troglitazone results in decreased expression of SOD2 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [troglitazone results in decreased expression of SOD2 protein]PMID:23964924
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