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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2294
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccne1
Name: cyclin E1
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccne1decreases expressionISOCCNE1 (Homo sapiens)6480464CTDtroglitazone results in decreased expression of CCNE1 proteinPMID:11834241 PMID:15729575 PMID:20540935
Ccne1multiple interactionsISOCCNE1 (Homo sapiens)6480464CTD[N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B protein] results in increased susceptibility to [troglitazone results in decreased expression of CCNE1 protein]; GSK3B protein affects the susceptibility to [troglitazone results in decreased expression of CCNE1 protein]PMID:20540935
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