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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11062
Species: Mus musculus
RGD Object: Gene
Symbol: Pck1
Name: phosphoenolpyruvate carboxykinase 1, cytosolic
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pck1increases expressionEXP 6480464CTDtroglitazone results in increased expression of PCK1 mRNAPMID:12732648
Pck1decreases expressionISOPck1 (Rattus norvegicus)6480464CTDtroglitazone results in decreased expression of PCK1 mRNAPMID:10446394 PMID:11597575
Pck1increases expressionISOPCK1 (Homo sapiens)6480464CTDtroglitazone results in increased expression of PCK1 mRNAPMID:28934090
Pck1multiple interactionsISOPck1 (Rattus norvegicus)6480464CTD[troglitazone co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in decreased expression of PCK1 mRNA; [troglitazone co-treated with Sirolimus] results in decreased expression of PCK1 mRNA; [troglitazone co-treated with wortmannin] results in decreased expression of PCK1 mRNAPMID:10446394
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