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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:9747
Term: Triptolide
Definition: An oxacycle that has formula C20H24O6.
Chemical ID: MESH:C001899
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[triptolide co-treated with catalpol] results in increased expression of NQO1 protein, [triptolide co-treated with Saponins] results in increased expression of NQO1 protein, catalpol promotes the reaction [[triptolide co-treated with Saponins] results in increased expression of NQO1 protein], Saponins promotes the reaction [[triptolide co-treated with catalpol] results in increased expression of NQO1 protein]

PMID:30682494
decreases expressionISORGD:104736480464CTDtriptolide results in decreased expression of NQO1 mRNA, triptolide results in decreased expression of NQO1 protein

PMID:25169008, PMID:30836114
decreases expressionISORGD:25036480464CTDtriptolide results in decreased expression of NQO1 protein

PMID:25169008
multiple interactionsISORGD:104736480464CTD10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of NQO1 mRNA], 10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [triptolide results in decreased expression of NQO1 protein]

PMID:30836114
multiple interactionsISORGD:25036480464CTDNFE2L2 protein inhibits the reaction [triptolide results in decreased expression of NQO1 protein]

PMID:25169008
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.