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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 71016
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp8b1
Name: cytochrome P450 family 8 subfamily B member 1
Acc ID: CHEBI:9747
Term: Triptolide
Definition: An oxacycle that has formula C20H24O6.
Chemical ID: MESH:C001899
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp8b1decreases expressionISOCyp8b1 (Mus musculus)6480464CTDtriptolide results in decreased expression of CYP8B1 mRNAPMID:32835833 PMID:32987112
Cyp8b1multiple interactionsISOCyp8b1 (Mus musculus)6480464CTD[triptolide co-treated with Lipopolysaccharides] results in decreased expression of CYP8B1 protein; TRAJ18 protein affects the reaction [triptolide results in decreased expression of CYP8B1 mRNA]PMID:32987112 PMID:36328986
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