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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62373
Species: Mus musculus
RGD Object: Gene
Symbol: Hes1
Name: hes family bHLH transcription factor 1
Acc ID: CHEBI:9747
Term: Triptolide
Definition: An oxacycle that has formula C20H24O6.
Chemical ID: MESH:C001899
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hes1decreases expressionEXP 6480464CTDtriptolide results in decreased expression of HES1 proteinPMID:30394310
Hes1increases expressionEXP 6480464CTDtriptolide results in increased expression of HES1 mRNAPMID:31241159
Hes1multiple interactionsEXP 6480464CTDFenofibrate inhibits the reaction [triptolide results in increased expression of HES1 mRNA]; NOTCH1 protein modified form inhibits the reaction [triptolide results in decreased expression of HES1 protein]PMID:30394310 PMID:31241159
Hes1decreases expressionISOHES1 (Homo sapiens)6480464CTDtriptolide results in decreased expression of HES1 mRNA; triptolide results in decreased expression of HES1 proteinPMID:30394310
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