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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2500
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Dhfr
Name: dihydrofolate reductase
Acc ID: CHEBI:9737
Term: trimetrexate
Definition: A quinazoline that has formula C19H23N5O3.
Chemical ID: MESH:D016597
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Dhfrdecreases response to substanceISODHFR (Homo sapiens)6480464CTDDHFR protein polymorphism results in decreased susceptibility to TrimetrexatePMID:12872145
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