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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1585162
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tpmt
Name: thiopurine S-methyltransferase
Acc ID: CHEBI:9683
Term: trichlormethiazide
Definition: A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension.
Chemical ID: MESH:D014237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tpmtdecreases activityISOTPMT (Homo sapiens)6480464CTDTrichlormethiazide results in decreased activity of TPMT proteinPMID:8866635
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