GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2a5 | decreases activity | ISO | CYP2A6 (Homo sapiens) | 6480464 | CTD | Tranylcypromine results in decreased activity of CYP2A6 protein | PMID:10911933 PMID:11353760 PMID:15155557 PMID:15980104 PMID:19328226 PMID:21336516 PMID:21915887 PMID:26599973 PMID:32496054 PMID:33253783 | Cyp2a5 | multiple interactions | ISO | CYP2A6 (Homo sapiens) | 6480464 | CTD | [[Tranylcypromine results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin; [Tranylcypromine results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin; [Tranylcypromine results in decreased activity of CYP2A6 protein] which results in decreased metabolism of coumarin; Tranylcypromine inhibits the reaction [[CYP2A6 protein results in increased metabolism of Methimazole] which results in increased abundance of N-methylthiourea]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased abundance of N-methylthiourea]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased chemical synthesis of 7-hydroxycoumarin]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased glutathionylation of Lamotrigine]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased metabolism of coumarin]; Tranylcypromine inhibits the reaction [CYP2A6 protein results in increased metabolism of Nicotine] | PMID:11353760 PMID:19961160 PMID:21915887 PMID:26599973 PMID:32496054 PMID:34788025 | | ||||||||||||||||||||||
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