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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1603576
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC47A2
Name: solute carrier family 47 member 2
Acc ID: CHEBI:9648
Term: tramadol
Definition: A racemate consisting of equal amounts of (R,R)- and (S,S)-tramadol. A centrally acting synthetic opioid analgesic, used (as the hydrochloride salt) to treat moderately severe pain. The (R,R)-enantiomer exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. Originally developed by Gruenenthal GmbH and launched in 1977, it was subsequently isolated from the root bark of the South African tree Nauclea latifolia.
Chemical ID: MESH:D014147
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC47A2multiple interactionsEXP 6480464CTDTramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]PMID:22419765
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