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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593276
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pdk3
Name: pyruvate dehydrogenase kinase 3
Acc ID: CHEBI:9648
Term: tramadol
Definition: A racemate consisting of equal amounts of (R,R)- and (S,S)-tramadol. A centrally acting synthetic opioid analgesic, used (as the hydrochloride salt) to treat moderately severe pain. The (R,R)-enantiomer exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. Originally developed by Gruenenthal GmbH and launched in 1977, it was subsequently isolated from the root bark of the South African tree Nauclea latifolia.
Chemical ID: MESH:D014147
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdk3increases expressionISORGD:13431636480464CTDTramadol results in increased expression of PDK3 mRNA

PMID:27317026
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