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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3171
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkbia
Name: NFKB inhibitor alpha
Acc ID: CHEBI:9642
Term: N-tosyl-L-phenylalanyl chloromethyl ketone
Definition: The N-tosyl derivative of L-phenylalanyl chloromethyl ketone.
Chemical ID: MESH:D014108
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkbiamultiple interactionsEXP 6480464CTDTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Acetaldehyde results in increased degradation of NFKBIA protein]PMID:17952619
Nfkbiadecreases degradationISONFKBIA (Homo sapiens)6480464CTDTosylphenylalanyl Chloromethyl Ketone results in decreased degradation of NFKBIA proteinPMID:12574206
Nfkbiadecreases phosphorylationISONFKBIA (Homo sapiens)6480464CTDTosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIA proteinPMID:10381628
Nfkbiamultiple interactionsISONfkbia (Mus musculus)6480464CTDTosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]PMID:10921504 PMID:18449507 PMID:18666753 PMID:9580637
Nfkbiamultiple interactionsISONFKBIA (Homo sapiens)6480464CTD[Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of RELA protein] inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; [Tosylphenylalanyl Chloromethyl Ketone results in decreased expression of RELA protein] inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]PMID:15687330 PMID:16288038
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