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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620809
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc12a2
Name: solute carrier family 12 member 2
Acc ID: CHEBI:9637
Term: torasemide
Definition: An N-sulfonylurea obtained by formal condensation of [(3-methylphenyl)amino]pyridine-3-sulfonic acid with the free amino group of N-isopropylurea. It is a potent loop diuretic used for the treatment of hypertension and edema in patients with congestive heart failure.
Chemical ID: MESH:C026116
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc12a2decreases activityISORGD:7328166480464CTDTorsemide results in decreased activity of SLC12A2 protein

PMID:29959396
Slc12a2multiple interactionsISORGD:7328166480464CTDTorsemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]

PMID:29959396
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