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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1607087
Species: Homo sapiens
RGD Object: Gene
Symbol: PIGA
Name: phosphatidylinositol glycan anchor biosynthesis class A
Acc ID: CHEBI:9570
Term: Thiotepa
Definition: An aziridine that has formula C6H12N3PS.
Chemical ID: MESH:D013852
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PIGAincreases mutagenesisISOPiga (Rattus norvegicus)6480464CTDThiotepa results in increased mutagenesis of PIGAPMID:22923490
PIGAmultiple interactionsISOPiga (Rattus norvegicus)6480464CTDThiotepa results in increased mutagenesis of and results in decreased activity of PIGA proteinPMID:27931811
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