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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308496
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mocos
Name: molybdenum cofactor sulfurase
Acc ID: CHEBI:9555
Term: tioguanine
Definition: A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia.
Chemical ID: MESH:D013866
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mocosmultiple interactionsISOMOCOS (Homo sapiens)6480464CTD[MOCOS gene SNP results in decreased oxidation of Mercaptopurine] which results in increased chemical synthesis of ThioguaninePMID:29935280
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