Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsp90b1
Name: heat shock protein 90 beta family member 1
Acc ID: CHEBI:9516
Term: thapsigargin
Definition: An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.
Chemical ID: MESH:D019284
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsp90b1increases expressionEXP 6480464CTDThapsigargin results in increased expression of HSP90B1 proteinPMID:17416481 PMID:35544339
Hsp90b1decreases expressionISOHSP90B1 (Homo sapiens)6480464CTDThapsigargin results in decreased expression of HSP90B1 mRNAPMID:19442820
Hsp90b1increases expressionISOHSP90B1 (Homo sapiens)6480464CTDThapsigargin results in increased expression of HSP90B1 mRNA; Thapsigargin results in increased expression of HSP90B1 proteinPMID:15292203 PMID:17416481 PMID:22378314 PMID:27587023 PMID:29453283
Hsp90b1increases expressionISOHsp90b1 (Mus musculus)6480464CTDThapsigargin results in increased expression of HSP90B1 proteinPMID:20493918
Hsp90b1multiple interactionsISOHSP90B1 (Homo sapiens)6480464CTD4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of HSP90B1 mRNA]PMID:19442820
Hsp90b1multiple interactionsISOHsp90b1 (Mus musculus)6480464CTDApigenin inhibits the reaction [Thapsigargin results in increased expression of HSP90B1 protein]; Thapsigargin promotes the reaction [arsenic trioxide results in increased expression of HSP90B1 protein]PMID:20493918 PMID:27638049
Go Back to source page   Continue to Ontology report