GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2c6 | increases hydroxylation | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 protein results in increased hydroxylation of Thalidomide | PMID:20443640 | Cyp2c6 | increases oxidation | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | CYP2C19 protein results in increased oxidation of Thalidomide | PMID:24350712 | Cyp2c6 | multiple interactions | ISO | CYP2C19 (Homo sapiens) | 6480464 | CTD | [CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5'-hydroxythalidomide; [CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5'-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5-hydroxythalidomide | PMID:20443640 PMID:24350712 | | ||||||||||||||||||||||
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