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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551562
Species: Mus musculus
RGD Object: Gene
Symbol: Crbn
Name: cereblon
Acc ID: CHEBI:9513
Term: thalidomide
Definition: A racemate comprising equimolar amounts of R- and S-thalidomide.
Chemical ID: MESH:D013792
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Crbnaffects bindingEXP 6480464CTDThalidomide binds to [CRBN protein binds to DDB1 protein]PMID:25108355
Crbnaffects bindingISOCRBN (Homo sapiens)6480464CTDThalidomide binds to [SALL4 protein binds to CRBN protein]; Thalidomide binds to CRBN proteinPMID:27751757 PMID:30067223
Crbnaffects response to substanceISOCRBN (Homo sapiens)6480464CTDCRBN gene SNP affects the susceptibility to ThalidomidePMID:27751757
Crbnmultiple interactionsISOCRBN (Homo sapiens)6480464CTDThalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]PMID:25043012
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