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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731027
Species: Homo sapiens
RGD Object: Gene
Symbol: BDNF
Name: brain derived neurotrophic factor
Acc ID: CHEBI:9506
Term: tetrodotoxin
Definition: A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.
Chemical ID: MESH:D013779
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BDNFmultiple interactionsEXP 6480464CTD3,5-dichloro-N-(1-(2,2-dimethyltetrahydropyran-4-ylmethyl)-4-fluoropiperidin-4-ylmethyl)benzamide promotes the reaction [Tetrodotoxin inhibits the reaction [Oxygen deficiency promotes the reaction [BDNF protein results in increased transport of Calcium]]]; Tetrodotoxin inhibits the reaction [Oxygen deficiency promotes the reaction [BDNF protein results in increased transport of Calcium]]PMID:26095976
BDNFmultiple interactionsISOBdnf (Mus musculus)6480464CTDTetrodotoxin inhibits the reaction [Azacitidine results in decreased methylation of BDNF promoter]; Tetrodotoxin inhibits the reaction [Azacitidine results in increased expression of BDNF mRNA]PMID:18184782
BDNFmultiple interactionsISOBdnf (Rattus norvegicus)6480464CTDTetrodotoxin inhibits the reaction [decamethrin results in increased expression of BDNF mRNA]; Tetrodotoxin inhibits the reaction [Veratridine results in increased expression of BDNF mRNA]PMID:16166269
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