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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70368
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acot8
Name: acyl-CoA thioesterase 8
Acc ID: CHEBI:94686
Term: orlistat
Definition: A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.
Chemical ID: MESH:C055122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:703726480464CTDOrlistat results in decreased expression of ACOT8 protein

PMID:30667213
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.