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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1607086
Species: Homo sapiens
RGD Object: Gene
Symbol: SKP2
Name: S-phase kinase associated protein 2
Acc ID: CHEBI:94686
Term: orlistat
Definition: A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.
Chemical ID: MESH:C055122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SKP2decreases expressionEXP 6480464CTDorlistat results in decreased expression of SKP2 proteinPMID:15138278
SKP2multiple interactionsEXP 6480464CTD[orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 proteinPMID:15138278
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