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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605125
Species: Homo sapiens
RGD Object: Gene
Symbol: ERN1
Name: endoplasmic reticulum to nucleus signaling 1
Acc ID: CHEBI:94686
Term: orlistat
Definition: A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.
Chemical ID: MESH:C055122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ERN1multiple interactionsEXP 6480464CTDorlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA]PMID:17283163
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