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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628600
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fmo2
Name: flavin containing dimethylaniline monoxygenase 2
Acc ID: CHEBI:94563
Term: benzydamine
Definition: A member of the class of indazoles carrying benzyl and 3-(dimethylamino)propyl groups at positions 1 and 3 respectively. A locally-acting nonsteroidal anti-inflammatory drug that also exhibits local anaesthetic and analgesic properties.
Chemical ID: MESH:D001591
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fmo2increases oxidationISORGD:7336276480464CTDFMO2 protein results in increased oxidation of Benzydamine

PMID:26062974
Fmo2multiple interactionsISORGD:7336276480464CTD[FMO2 protein results in increased oxidation of Benzydamine] which results in increased chemical synthesis of benzydamine N-oxide

PMID:26062974
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