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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nqo2
Name: N-ribosyldihydronicotinamide:quinone reductase 2
Acc ID: CHEBI:945
Term: 2,6-dichloroindophenol
Definition: A quinone imine that is indophenol substituted by chloro groups at positions 2 and 6.
Chemical ID: MESH:D015086
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo2increases reductionISORGD:13516296480464CTDNQO2 protein results in increased reduction of 2,6-DichloroindophenolPMID:29281794
Nqo2multiple interactionsISORGD:13516296480464CTD[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of 2,6-Dichloroindophenol; [NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of 2,6-Dichloroindophenol; resveratrol inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol]; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of 2,6-Dichloroindophenol]PMID:20399199 PMID:29281794
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