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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620020
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptger2
Name: prostaglandin E receptor 2
Acc ID: CHEBI:9448
Term: terbinafine
Definition: A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections.
Chemical ID: MESH:C041359
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptger2increases response to substanceISORGD:13428846480464CTDPTGER2 protein results in increased susceptibility to terbinafinePMID:16784723
Ptger2multiple interactionsISORGD:13428846480464CTDPTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]PMID:16784723
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