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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2561
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Acc ID: CHEBI:9442
Term: tephrosin
Definition: A member of the class of rotenones that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted with geminal methyl groups at position 3, hydroxy group at position 7a and methoxy groups at positions 9 and 10 (the 7aR,13aR stereoisomer). It is isolated from the leaves and twigs of Antheroporum pierrei and exhibits antineoplastic and pesticidal activities.
Chemical ID: MESH:C480848
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb2affects localizationISORGD:6195636480464CTDtephrosin affects the localization of ERBB2 protein

PMID:20056314
Erbb2multiple interactionsISORGD:6195636480464CTDChloroquine inhibits the reaction [tephrosin results in increased degradation of ERBB2 protein], tephrosin inhibits the reaction [EGF protein affects the phosphorylation of ERBB2 protein], tephrosin inhibits the reaction [NRG1 protein affects the phosphorylation of ERBB2 protein], tephrosin results in increased degradation of and results in decreased phosphorylation of ERBB2 protein

PMID:20056314
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.