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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10864
Species: Mus musculus
RGD Object: Gene
Symbol: Ldlr
Name: low density lipoprotein receptor
Acc ID: CHEBI:94385
Term: (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid
Definition: A peptide that has formula C23H36N6O5S.
Chemical ID: MESH:C031942
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldlrmultiple interactionsEXP 6480464CTDargatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Cholesterol]; argatroban inhibits the reaction [[LDLR gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Triglycerides]PMID:22841818
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