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Pathways

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69051
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:9401
Term: taraxasterol
Definition: A pentacyclic triterpenoid that is taraxastane with a β-hydroxy group at position 3.
Chemical ID: MESH:C079988
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTDLithium Chloride inhibits the reaction [taraxasterol inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]]; Lithium Chloride inhibits the reaction [taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]]; taraxasterol inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]; taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of CTNNB1 protein]; taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]; taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of MMP9 protein]; taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; taraxasterol inhibits the reaction [TGFB1 protein results in increased expression of WNT3A protein]PMID:34219514
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