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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620248
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb4
Name: ATP binding cassette subfamily B member 4
Acc ID: CHEBI:9398
Term: tamsulosin
Definition: A 5-(2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzenesulfonamide that has (R)-configuration. A specific alpha1 adrenoceptor antagonist used (generally as its hydrochloride salt, tamsulosin hydrochloride) in the treatment of prostatic hyperplasia, chronic prostatitis, urinary retention, and help with the passage of kidney stones.
Chemical ID: MESH:C088482
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb4decreases activityISOABCB4 (Homo sapiens)6480464CTDtamsulosin results in decreased activity of ABCB4 proteinPMID:28437613
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