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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69101
Species: Homo sapiens
RGD Object: Gene
Symbol: GH1
Name: growth hormone 1
Acc ID: CHEBI:9381
Term: T-2 toxin
Definition: A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.
Chemical ID: MESH:D013605
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GH1decreases expressionISOGh1 (Rattus norvegicus)6480464CTDT-2 Toxin results in decreased expression of GH1 mRNAPMID:26141394 PMID:29079362
GH1multiple interactionsISOGh1 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]; AKNA protein affects the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]; farnesylthiosalicylic acid inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]; SB 203580 inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA]; T-2 Toxin results in decreased expression of and results in decreased secretion of GH1 proteinPMID:26141394 PMID:29079362
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