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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620436
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cga
Name: glycoprotein hormones, alpha polypeptide
Acc ID: CHEBI:9381
Term: T-2 Toxin
Definition: A trichothecene that has formula C24H34O9.
Chemical ID: MESH:D013605
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:13485906480464CTDT-2 Toxin inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of AREG mRNA], T-2 Toxin inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of EREG mRNA], T-2 Toxin inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of PGR mRNA]

PMID:30951242
multiple interactionsISORGD:7318386480464CTD[T-2 Toxin co-treated with CGA protein] results in decreased activity of CYP11A1 protein, [T-2 Toxin co-treated with CGA protein] results in decreased activity of CYP17A1 protein, [T-2 Toxin co-treated with CGA protein] results in decreased activity of STAR protein, [T-2 Toxin co-treated with CGA protein] results in decreased expression of CYP11A1 mRNA, [T-2 Toxin co-treated with CGA protein] results in decreased expression of STAR mRNA

PMID:25962641
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.