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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348590
Species: Homo sapiens
RGD Object: Gene
Symbol: CGA
Name: glycoprotein hormones, alpha polypeptide
Acc ID: CHEBI:9381
Term: T-2 toxin
Definition: A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.
Chemical ID: MESH:D013605
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CGAmultiple interactionsEXP 6480464CTDT-2 Toxin inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of AREG mRNA]; T-2 Toxin inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of EREG mRNA]; T-2 Toxin inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of PGR mRNA]PMID:30951242
CGAmultiple interactionsISOCga (Mus musculus)6480464CTD[T-2 Toxin co-treated with CGA protein] results in decreased activity of CYP11A1 protein; [T-2 Toxin co-treated with CGA protein] results in decreased activity of CYP17A1 protein; [T-2 Toxin co-treated with CGA protein] results in decreased activity of STAR protein; [T-2 Toxin co-treated with CGA protein] results in decreased expression of CYP11A1 mRNA; [T-2 Toxin co-treated with CGA protein] results in decreased expression of STAR mRNAPMID:25962641
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