Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10823
Species: Mus musculus
RGD Object: Gene
Symbol: Jak2
Name: Janus kinase 2
Acc ID: CHEBI:9381
Term: T-2 toxin
Definition: A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.
Chemical ID: MESH:D013605
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jak2increases expressionEXP 6480464CTDT-2 Toxin results in increased expression of JAK2 mRNAPMID:22454431
Jak2multiple interactionsEXP 6480464CTDalpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [T-2 Toxin results in increased expression of JAK2 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of JAK2 mRNA]PMID:22454431
Jak2decreases expressionISOJAK2 (Homo sapiens)6480464CTDT-2 Toxin results in decreased expression of JAK2 mRNAPMID:34581912
Go Back to source page   Continue to Ontology report