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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:92948
Term: 3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxybenzamide
Definition: A dimethoxybenzene that has formula C16H23BrN2O3.
Chemical ID: MESH:D017330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2affects bindingEXP 6480464CTDRemoxipride binds to DRD2 proteinPMID:7901417
Drd2multiple interactionsEXP 6480464CTD[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine; [Remoxipride results in decreased activity of DRD2 protein] inhibits the reaction [Dopamine results in decreased susceptibility to Pilocarpine]; Remoxipride binds to and results in decreased activity of DRD2 protein; Remoxipride inhibits the reaction [N-n-propylnorapomorphine binds to DRD2 protein]; Remoxipride inhibits the reaction [Spiperone binds to DRD2 protein]PMID:15140183 PMID:1724532 PMID:6149133
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