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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737312
Species: Homo sapiens
RGD Object: Gene
Symbol: AGER
Name: advanced glycosylation end-product specific receptor
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AGERincreases expressionISOAger (Rattus norvegicus)6480464CTDStreptozocin results in increased expression of AGER mRNA; Streptozocin results in increased expression of AGER proteinPMID:22476978 PMID:25199697 PMID:31009641
AGERincreases expressionISOAger (Mus musculus)6480464CTDStreptozocin results in increased expression of AGER mRNAPMID:19833897
AGERincreases response to substanceISOAger (Mus musculus)6480464CTDAGER protein results in increased susceptibility to StreptozocinPMID:27109771
AGERmultiple interactionsISOAger (Rattus norvegicus)6480464CTD[Glyburide co-treated with Dimethyl Fumarate] inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; [Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein; Dimethyl Fumarate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; Glyburide inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; Kangen-karyu inhibits the reaction [Streptozocin results in increased expression of AGER protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of AGER protein]; Sodium Selenite inhibits the reaction [Streptozocin results in increased expression of AGER protein]; Zinc inhibits the reaction [Streptozocin results in increased expression of AGER mRNA]PMID:19397970 PMID:22476978 PMID:25199697 PMID:31009641 PMID:36999408
AGERmultiple interactionsISOAger (Mus musculus)6480464CTDmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Streptozocin results in increased expression of AGER mRNA]PMID:19833897
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