GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PPARA | affects response to substance | ISO | Ppara (Mus musculus) | 6480464 | CTD | PPARA protein affects the susceptibility to Streptozocin | PMID:16306367 | PPARA | decreases expression | ISO | Ppara (Rattus norvegicus) | 6480464 | CTD | Streptozocin results in decreased expression of PPARA mRNA; Streptozocin results in decreased expression of PPARA protein | PMID:12967931 PMID:23647015 PMID:25246140 | PPARA | decreases expression | ISO | Ppara (Mus musculus) | 6480464 | CTD | Streptozocin results in decreased expression of PPARA mRNA | PMID:23927877 | PPARA | increases expression | ISO | Ppara (Rattus norvegicus) | 6480464 | CTD | Streptozocin results in increased expression of PPARA protein | PMID:28648635 | PPARA | increases expression | ISO | Ppara (Mus musculus) | 6480464 | CTD | Streptozocin results in increased expression of PPARA mRNA | PMID:34896238 | PPARA | multiple interactions | ISO | Ppara (Rattus norvegicus) | 6480464 | CTD | [[Streptozocin co-treated with Carbamazepine] affects the susceptibility to Dietary Fats] which results in decreased expression of PPARA mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of PPARA mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of PPARA protein; [Streptozocin co-treated with Cadmium] results in decreased expression of PPARA protein; Allopurinol inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]; Allopurinol inhibits the reaction [Streptozocin results in decreased expression of PPARA protein]; Bezafibrate inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]; idebenone inhibits the reaction [Streptozocin results in increased expression of PPARA protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of PPARA protein]; Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PPARA mRNA]; Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PPARA protein]; Quercetin inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]; Quercetin inhibits the reaction [Streptozocin results in decreased expression of PPARA protein] | PMID:12967931 PMID:23647015 PMID:25240712 PMID:28648635 PMID:29614383 PMID:35786680 | PPARA | multiple interactions | ISO | Ppara (Mus musculus) | 6480464 | CTD | [Dietary Fats co-treated with Streptozocin] results in decreased expression of PPARA mRNA; [Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARA protein; Acrylamide inhibits the reaction [Streptozocin results in increased expression of PPARA mRNA]; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PPARA mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]; naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARA protein]; puerarin inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA] | PMID:23927877 PMID:29988851 PMID:31063766 PMID:34896238 | | ||||||||||||||||||||||
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